Recent Research

 
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 Publications

  1. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Zekavat, S.M., Lin, SH., Bick, A.G. et al. 2021 Jun. Nat Med. 27, 1012–1024. doi: https://doi.org/10.1038/s41591-021-01371-0

  2. Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Daniel Nachun, Ake T. Lu, Alexander G. Bick, et al. 2021 May; doi: https://doi.org/10.1111/acel.13366

  3. Germline risk of clonal haematopoiesis. Silver, A.J., Bick, A.G. & Savona, M.R. 2021 Mar. Nat Rev Genet; doi: https://doi.org/10.1038/s41576-021-00356-6

  4. Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential. Tetsushi Nakao, Alexander G. Bick, et al. 2021 Feb. medRxiv, 21252199; doi: https://doi.org/10.1101/2021.02.26.21252199

  5. Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women. Michael C. Honigberg, Seyedeh M. Zekavat, Abhishek Niroula, Gabriel K. Griffin, Alexander G. Bick, et al. Circulation. 2020 Nov. 2021; 143: 410–423; doi: https://doi.org/10.1161/CIRCULATIONAHA.120.051775

  6. Increased CHIP Prevalence Amongst People Living with HIV. Alexander G. Bick, Konstantin Popadin, et al. 2020 Nov. medRxiv, 20225607; doi: https://doi.org/10.1101/2020.11.06.20225607

  7. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Bick, A.G., Weinstock, J.S., Nandakumar, S.K. et al. Nature. 2020 Jul. 586, 763–768; doi: https://doi.org/10.1038/s41586-020-2819-2

  8. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Alexander G. Bick, James P. Pirruccello, et al. 2020 Nov. 141: 124–131; doi: https://doi.org/10.1161/CIRCULATIONAHA.119.044362

  9. Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer. Seyedeh M. Zekavat, Shu-Hong Lin, Alexander G. Bick, et al. 2020 Nov. medRxiv, 20230821; doi: https://doi.org/10.1101/2020.11.12.20230821

  10. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, Alexander G. Bick, et al. Nature. 2020 Oct. 586, 769–775; doi: https://doi.org/10.1038/s41586-020-2786-7

  11. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Akl C. Fahed, Minxian Wang, Julian R. Homburger, Aniruddh P. Patel, Alexander G. Bick, et al. Nat Commun. 2020 Aug. 11, 3635; doi: https://doi.org/10.1038/s41467-020-17374-3

  12. Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy. Pirruccello, J.P., Bick, A., Wang, M. et al. Nat Commun. 2020 Jul. 11, 2254; doi: https://doi.org/10.1038/s41467-020-15823-7

  13. Proteomic Profiling in Biracial Cohorts Implicates DC-SIGN as a Mediator of Genetic Risk in COVID-19. Daniel H. Katz, Usman A. Tahir, Debby Ngo, Mark Benson, Alexander G. Bick, et al. 2020 June. medRxiv, 20125690; doi: https://doi.org/10.1101/2020.06.09.20125690

  14. Parenting While in Training: A Comprehensive Needs Assessment of Residents and Fellows. Kirti Magudia, Thomas S. C. Ng, Alexander G. Bick, et al. J Grad Med Educ. 2020 Apr. 12 (2): 162–167; doi: https://doi.org/10.4300/JGME-D-19-00563.1

  15. Titin Truncating Variants in Adults Without Known Congestive Heart Failure. James P. Pirruccello, Alexander Bick, et al. J Am Coll Cardiol. 2020 Mar. 75 (10) 1239–1241; doi: https://doi.org/10.1016/j.jacc.2020.01.013

  16. Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathy. James P. Pirruccello, Alexander Bick, et al. 2020 Feb. bioRxiv, 946038; doi: https://doi.org/10.1101/2020.02.12.946038

  17. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Alexander G. Bick, Elvis Akwo, et al. 2019 Aug. 140: 1031–1040; doi: https://doi.org/10.1161/CIRCULATIONAHA.118.036589

  18. Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure. James P. Pirruccello, Alexander Bick, et al. 2019 Aug. medRxiv 19005058; doi: https://doi.org/10.1101/19005058

  19. Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. Sumeet A. Khetarpal, Arman Qamar, Alexander G. Bick, et al. J Am Coll Cardiol. 2019 Jul. 74 (4) 578–586; doi: https://doi.org/10.1016/j.jacc.2019.05.045